Mexico comfortably beat Ghana in an International friendly to hand Chris Hughton his first defeat as the head coach of the Black Stars.
The Irish-born gaffer had hoped to continue his unbeaten run since his appointment in March, having won three and drawn two matches in all competitions.
His target seemed to be on course at the Bank of America Stadium before the South Americans took the lead 12 minutes inside the second half.
Harven Lozano netted a fine finish before Uriel Antuna sealed the win in the 71st minute.
Mohammed Kudus came close to scoring by firing a shot which was deflected and went out of play.
Ghana ended the game without a shot on target.
To add to their woes, centre-back Joseph Aidoo was injured and had to be replaced by Alidu Seidu.
The Black Stars will hope to redeem themselves in the next friendly against United States of America