Daniel Afriyie Barnieh and Rahim Ibrahim both scored twice for their clubs over the weekend, while Benjamin Tetteh and Osman Bukari were also among the Ghanaian players to make a significant impact.
Barnieh scored both goals as FC Aarau defeated FC Zurich 2-0 on Sunday, October 18, securing their place in the Swiss Cup Round of 16.
The former Hearts of Oak striker has continued his strong run in front of goal and now has three goals and two assists this season.
Matthew Cudjoe opened his account for the campaign as Bnei Sakhnin beat Hapoel Petah Tikva 2-0 on Saturday, October 17.
The Ghanaian forward attempted more shots on target than any other player in the match, with four. He has now contributed three goals and one assist from 12 appearances this season.
Rahim Ibrahim produced an outstanding display for Slovan Bratislava, scoring twice in their 3-0 win over Spartak Trnava in the Slovak league.
The midfielder completed 95 per cent of his passes and has scored four goals in seven appearances across all competitions this season.
Osman Bukari played the full 90 minutes and scored for Red Star Belgrade in their 5-1 victory against Mladost Lucani in the Serbian SuperLiga.
The winger completed both of his attempted dribbles, created four chances, had one shot on target and made five recoveries.
Augustine Boakye did not score for the first time in seven matches but remained influential as Saint-Etienne secured a 1-0 win over Red Star.
Boakye completed a match-high three dribbles, created one big chance and made seven interceptions. He has five goals and three assists from nine appearances this season.
Benjamin Tetteh maintained his impressive form for Kalba, scoring once and setting up another goal in their 2-2 draw with Al Jazira in the UAE Pro League.
The forward has now scored and provided an assist in consecutive matches, taking his season total to three goals and three assists in six league appearances.
Abdul Fatawu Issahaku made an impact after coming off the bench for Leicester City, winning the penalty from which his side scored in their 3-2 defeat by Manchester City.
The Ghanaian winger played 19 minutes and completed three dribbles, more than any other player in the match.
Antoine Semenyo also appeared as a substitute, playing 13 minutes in his first substitute appearance in the Premier League this season.
In Turkey, Jesurun Rak-Sakyi supplied an assist as Kasımpasa beat Samsunspor 4-1.
The Ghanaian winger created five chances during his 86 minutes on the pitch, the highest total recorded by any player in the match. He now has one goal and one assist from four appearances this season.