Medeama SC have a first-leg advantage after beating Horoya 3-1 in the second round of the CAF Champions League at the Cape Coast Stadium.
The opening exchanges did little to provide decent opportunities, though the hosts were on the front foot in the first 45 minutes.
Striker Jonathan Sowah had the chance to put Medeama ahead two minutes into the second half but his strike was off target.
The rreward for the Ghana Premier League champions then paid off a minute later when Nana Kofi Babel struck the opener.
Abdulai Nurudeen rose highest to nod home the second in the 65th minute before Kofi Asmah added the third with a screamer.
The Guinean giants managed to give themselves a lifeline in the two legged tie after scoring a consolation.
The second leg is slated for September 30 in Conakry.
