Asante Kotoko travel to Accra to face Legon Cities at the El Wak Sports Stadium on Thursday afternoon as a new era begin under coach Abdul Gazale.
The betPawa Premier League Match Week 24 encounter is scheduled to kick off at exactly 4pm.
The acting head coach faces his first major test since taking over from the departed Seydou Zerbo.
Legon Cities has been struggling this season, and with relegation staring at them, they need to start picking points.
Meanwhile, the Porcupine Warriors will be looking to bounce back from their disappointing 2-0 defeat to Medeama SC on Sunday.
Kotoko has not been too impressive on the road, but can draw some confidence from their win against Samartex 1996 in their last away win.
Kotoko and Legon Cities played a 1-1 drawn game when they faced off in the first round.
