Black Stars captain Andre Ayew has been axed as Chris Hughton names 23 players for the upcoming international friendlies.
The 33-year-old is yet to find a club after parting ways with Nottingham Forest at the end of last season.
Baba Rahman has also been exempted from the squad.
But deputy captain, Thomas Partey, who missed September’s call-up after sustaining a groin injury, is back in the team.
Right-back Tariq lamptey has also been included following his injury return coupled with consistent performances for English Premier League side, Brighton.
Jordan Ayew, Mohammed Kudus, Antoine Semenyo have all kept their spots in the team from the last call-up.
Ghana face Mexico at the Bank of America stadium on October 14 before three days later, come up against the United States of America in Nashville Tennessee.
