Defending champions Asante Kotoko will begin their MTN FA Cup title defence against Division One League side Future Stars after the Round of 64 draw held on Friday, November 14.
Two-time champions Medeama SC have been matched with Rospak FC, while Sekondi Eleven Wise will battle Premier League high-flyers FC Samartex 1996.
Record winners Hearts of Oak have also been handed a lower-tier opponent, drawing third-tier side True Life FC. Elsewhere, Na God FC will face Accra Great Olympics, and Dreams FC have been paired with Semper FI.
All Round of 64 fixtures are scheduled for the weekend of November 25–27, 2025.
