Medeama SC will be without the services of Abdul Fatawu Hamidu and Theophilous Anobaah in their third group game against Young Africans in the CAF Champions League.
The two players picked up injuries in training ahead of the game.
The Yellow and Mauves are seeking a second victory in the competition when they tackle the Tanzanian side at the Baba Yara Stadium on Friday.
The Ghanaian Champions suffered a 3-0 defeat to Al Ahly SC in their first group game but recovered by beating Algerian side CR Belouizdad 2-1 in the second game.
The Tarkwa based club have attained three points and sit third on the standings.
Amadu Hamidu